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| Deborah Mayfair | |
| Continuity: | Lives of the Mayfair Witches |
| Notability: | Supporting character |
| Type: | Witch |
| Gender: | Female |
| Location: | Amsterdam |
| Associations: | Mayfair family |
| Relatives: | Earl of Donnelaith Suzanne Mayfair Charlotte Mayfair |
| Status: | Deceased |
| Born: | 1652 |
| Died: | 1689 |
| First: | The Witching Hour |
Deborah Mayfair is a fictional witch and a supporting character featured in the Lives of the Mayfair Witches line of novels by author Anne Rice. She appeared in the first book in the series, The Witching Hour, published in October, 1990.