2049 is the forty-ninth year of the 21st century. It follows 2048 and precedes 2050. As this is a time era that has yet to take place in the real world, all information regarding this year other than the previously stated is a matter of speculation and/or fiction.
On the Flash television series, 2049 is the year that Nora West-Allen was operating in the costumed guise of XS. It was from this year that she traveled back in time to the year 2018 to reconnect with her father, Barry Allen - years before he was destined to disappear during the great "Crisis".